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2-Chloroadenosine (CADO)

(HB2844)
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Product overview

Name 2-Chloroadenosine (CADO)
Alternative names 2-CADO
Purity >99%
Description Adenosine receptor agonist
Biological Data Solubility & Handling Chemical Data Related Areas Calculators Technical guides (1) Reviews References (4) Frequently bought together
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Biological Data

Biological description

Analog of adenosine. Adenosine receptor agonist (Ki values are 300, 80 and 1900 nM at A1, A2A and A3 receptors resepectively. Shows anticonvulsant activity. Active in vivo.

Also inhibits the induction of long-term potentiation (LTP).

Solubility & Handling

Solubility overview Soluble in water (25mM) and in DMSO (100mM)
Storage instructions +4°C
Storage of solutions Prepare and use solutions on the same day if possible. Store solutions at -20°C for up to one month if storage is required. Equilibrate to RT and ensure the solution is precipitate free before use.
Shipping Conditions Stable for ambient temperature shipping. Follow storage instructions on receipt.
Important This product is for RESEARCH USE ONLY and is not intended for therapeutic or diagnostic use. Not for human or veterinary use.

Calculators

Molarity

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Dilution

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Chemical Data

Purity >99%
Chemical name 6-Amino-2-chloropurine riboside
Molecular Weight 301.69
Chemical structure 2-Chloroadenosine [146-77-0] Chemical Structure
Molecular Formula C10H12ClN5O4
CAS Number 146-77-0
PubChem identifier 8974
SMILES C1=NC2=C(N1[C@H]3[C@@H]([C@@H]([C@H](O3)CO)O)O)N=C(N=C2N)Cl
InChi InChI=1S/C10H12ClN5O4/c11-10-14-7(12)4-8(15-10)16(2-13-4)9-6(19)5(18)3(1-17)20-9/h2-3,5-6,9,17-19H,1H2,(H2,12,14,15)/t3-,5-,6-,9-/m1/s1
InChiKey BIXYYZIIJIXVFW-UUOKFMHZSA-N
MDL number MFCD00005734
Appearance White solid

References for 2-Chloroadenosine (CADO)

References are publications that support the biological activity of the product

  • Effects of 2-chloroadenosine on cortical epileptic afterdischarges in immature rats.

    Pometlova et al (2010) Pharmacol Rep 62(1) : 62-7
    Read more (PubMedID: 20360616)

  • The protective effect of 2-chloroadenosine against the development of amygdala kindling and on amygdala-kindled seizures.

    Abdul-Ghani et al (1997) Eur J Pharmacol. 326(1) : 7-14
    Read more (PubMedID: 9178649)

  • Pharmacokinetic-haemodynamic relationships of 2-chloroadenosine at adenosine A1 and A2a receptors in vivo.

    Mathoot et al (1996) Br J Pharmacol 118(2) : 369-77
    Read more (PubMedID: 8735640)

  • 2-Chloroadenosine decreases long-term potentiation in the hippocampal CA1 area of the rat.

    de Mendonca et al (1990) Neurosci Lett 118(1) : 107-11
    Read more (PubMedID: 2259460)

4 Item(s)

Related Products
Grouped product items
Order: HB2844
Pack PriceQty
250mg
$337
1g
$863
Adenosine receptor agonist
Shipping Info

Standard: $35

Hazardous: $35

Shipped on ice: $35

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