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CIQ

(HB0197)
Publications (2)

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Product overview

Name CIQ
Purity >98%
Customer comments

We were happy with the CIQ indeed. Verified customer, University of Milan

Description GluN2C / GluN2D subunit selective NMDA receptor positive allosteric modulator
Biological Data Solubility & Handling Chemical Data Related Areas Calculators Technical guides (4) Reviews (1) Publications (2) References (3) Frequently bought together
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CIQ: Scientist Approved
CIQ: Scientist Approved
CIQ product vial image | Hello Bio
CIQ product vial image | Hello Bio

CIQ: Scientist Approved

CIQ: Scientist Approved

CIQ product vial image | Hello Bio

CIQ product vial image | Hello Bio

Biological Data

Biological description GluN2C / GluN2D subunit selective NMDA receptor positive allosteric modulator. Causes two-fold increase in receptor channel opening frequency (EC50 values are 2.7 and 2.8 µM for GluN2C and GluN2D respectively). Reduces associated behaviours in schizophrenia models and potentially enhances DA release in Parkinson's disease models.

Solubility & Handling

Solubility overview Soluble in DMSO (100mM) and in ethanol (10mM, sonication)
Storage instructions +4°C
Storage of solutions Prepare and use solutions on the same day if possible. Store solutions at -20°C for up to one month if storage is required. Equilibrate to RT and ensure the solution is precipitate free before use.
Shipping Conditions Stable for ambient temperature shipping. Follow storage instructions on receipt.
Important This product is for RESEARCH USE ONLY and is not intended for therapeutic or diagnostic use. Not for human or veterinary use.

Calculators

Molarity

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Dilution

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Chemical Data

Purity >98%
Chemical name (3-Chlorophenyl) [3,4-dihydro-6,7-dimethoxy-1-[(4-methoxyphenoxy)methyl]-2(1H)-isoquinolinyl]methanone
Molecular Weight 467.94
Chemical structure CIQ [486427-17-2] Chemical Structure
Molecular Formula C26H26ClNO5
CAS Number 486427-17-2
PubChem identifier 4231127
SMILES COC1=CC=C(C=C1)OCC2C3=CC(=C(C=C3CCN2C(=O)C4=CC(=CC=C4)Cl)OC)OC
InChi InChI=1S/C26H26ClNO5/c1-30-20-7-9-21(10-8-20)33-16-23-22-15-25(32-3)24(31-2)14-17(22)11-12-28(23)26(29)18-5-4-6-19(27)13-18/h4-10,13-15,23H,11-12,16H2,1-3H3
InChiKey VYMILMYEENZHAR-UHFFFAOYSA-N

References for CIQ

References are publications that support the biological activity of the product

  • Allosteric modulation of GluN2C/GluN2D-containing NMDA receptors bidirectionally modulates dop release: implication for Parkinson's disease.

    Zhang X et al (2014) Br J Pharmacol 171(16) : 3938-45.
    Read more (PubMedID: 24818560)

  • GluN2C/GluN2D subunit-selective NMDA receptor potentiator CIQ reverses MK-801-induced impairment in prepulse inhibition and working memory in Y-maze test in mice.

    Suryavanshi PS et al (2014) Br J Pharmacol 171(3) : 799-809.
    Read more (PubMedID: 24236947)

  • A subunit-selective potentiator of NR2C- and NR2D-containing NMDA receptors.

    Mullasseril P et al (2010) Nat Commun 1 : 90
    Read more (PubMedID: 20981015)

3 Item(s)

Publications
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These publications cite the use of CIQ purchased from Hello Bio:

  • The NMDA receptor intracellular C-terminal domains reciprocally interact with allosteric modulators.

    Sapkota et al (2019) Biochem Pharmacol 159 : 140-153
    PubMedID: 30503374

  • Functional and pharmacological properties of triheteromeric GluN1/2B/2D NMDA receptors

    Yi F et al (2019) J Physiol 597(22) : 5495-5514
    PubMedID: 31541561

2 Item(s)

Related Products
Grouped product items
Order: HB0197
Pack PriceQty
10mg
$182
50mg
$730
GluN2C / GluN2D subunit selective NMDA receptor positive allosteric modulator
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Standard: $35

Hazardous: $35

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