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Dexamethasone (water-soluble)

(HB6020)
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Product overview

Name Dexamethasone (water-soluble)
Purity >98%
Description

Water soluble formulation of dexamethasone: synthetic glucocorticoid with potent anti-inflammatory actions. Induces hMSC differentiation. Apoptosis inducer. Suitable for cell culture. 

Biological Data Solubility & Handling Chemical Data Related Areas Calculators Technical guides (2) Reviews (1) References (3) Frequently bought together
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Biological Data

Biological description

Synthetic glucocorticoid which shows potent anti-inflammatory and immunospressant effects.

Induces differentiation of mesenchymal stem cells (hMSCs) into adipogenic, chondrogenic and osteogenic lineages.

Commonly used with ascorbic acid and β-Gly for osteogenic differentiation of stem cells.


This is a water soluble compound composed of a dexamethasone – Cyclodextrin complex (Approx. 65 mg dexamethasone per gm. Balance 2-hydroxypropyl-β-cyclodextrin).

Recently investigated as part of COVID-19 compound repurposing.

Apoptosis inducer.

Dexamethasone free base also available.

 

Solubility & Handling

Solubility overview Soluble in water (100 mM)
Storage instructions -20°C (protect from light)
Storage of solutions Prepare and use solutions on the same day if possible. Store solutions at -20°C for up to one month if storage is required. Equilibrate to RT and ensure the solution is precipitate free before use.
Shipping Conditions Stable for ambient temperature shipping. Follow storage instructions on receipt.
Important This product is for RESEARCH USE ONLY and is not intended for therapeutic or diagnostic use. Not for human or veterinary use.

Calculators

Molarity

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More Info

Dilution

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Chemical Data

Purity >98%
Chemical name (11β,16α)-9-Fluoro-11,17,21-trihydroxy-16-methyl-pregna-1,4-diene-3,20-dione
Chemical structure Dexamethasone water soluble [50-02-2] Chemical Structure
Molecular Formula C22H29FO5.xC36H60O30
CAS Number 50-02-2
PubChem identifier 71308592
SMILES CC1CC2C3CCC4=CC(=O)C=CC4(C3C(CC2(C1C(=O)CO)C)O)C.C(C1C2C(C(C(O1)OC3C(OC(C(C3O)O)OC4C(OC(C(C4O)O)OC5C(OC(C(C5O)O)OC6C(OC(C(C6O)O)OC7C(OC(C(C7O)O)OC8C(OC(O2)C(C8O)O)CO)CO)CO)CO)CO)CO)O)O)O
InChi InChI=1S/C42H70O35.C22H30O4/c43-1-8-29-15(50)22(57)36(64-8)72-30-9(2-44)66-38(24(59)17(30)52)74-32-11(4-46)68-40(26(61)19(32)54)76-34-13(6-48)70-42(28(63)21(34)56)77-35-14(7-49)69-41(27(62)20(35)55)75-33-12(5-47)67-39(25(60)18(33)53)73-31-10(3-45)65-37(71
InChiKey XEJNDGTUKUMQNG-ARJMFYCQSA-N
MDL number MFCD00064136
Appearance White to off-white solid
Formulation Approximately 65 mg dexamethasone per gm. Balance 2-hydroxypropyl-β-cyclodextrin.

References for Dexamethasone (water-soluble)

References are publications that support the biological activity of the product

  • Dexamethasone alleviates tumor-associated brain damage and angiogenesis.

    Fan Z et al (2014) PLoS One 9(4) : e93264.
    Read more (PubMedID: 24714627)

  • Short bouts of mechanical loading are as effective as dexamethasone at inducing matrix production by human bone marrow mesenchymal stem cell.

    Sittichokechaiwut A et al (2010) Eur Cell Mater 20 : 45-57.
    Read more (PubMedID: 20648425)

  • Glucocorticoid receptor antagonism by cyproterone acetate and RU486.

    Honer C et al (2003) Mol Pharmacol 63(5) : 1012-20.
    Read more (PubMedID: 12695529)

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Order: HB6020
Pack PriceQty
100mg
$109

Water soluble formulation of dexamethasone: synthetic glucocorticoid with potent anti-inflammatory actions. Induces hMSC differentiation. Apoptosis inducer. Suitable for cell culture. 

Shipping Info

Standard: $35

Hazardous: $35

Shipped on ice: $35

Shipping will be calculated at checkout

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