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GsMTx4

(HB1161)
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Product overview

Name GsMTx4
Alternative names M-TRTx-Gr1a, M-theraphotoxin-Gr1a
Purity >95%
Description Piezo and TRP mechanosensitive channels inhibitor
Biological Data Solubility & Handling Chemical Data Related Areas Calculators Technical guides (1) Reviews References (6) Frequently bought together
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Biological Data

Biological description

Gating modifier peptide from spider venom which selectively inhibits mechanosensitive ion channels such as Piezo and TRP.

It is commonly used in the study mechanosensitive channels function in physiology and pathology.

It has also recently been reported to inhibit a stretch-activated BK channel (SAKcaC) and TACAN, a mechanosensitive ion channel involved in pain regulation.

Solubility & Handling

Solubility overview Soluble in water (1mg/ml)
Storage instructions -20°C
Storage of solutions Prepare and use solutions on the same day if possible. Store solutions at -20°C for up to one month if storage is required. Equilibrate to RT and ensure the solution is precipitate free before use.
Shipping Conditions Stable for ambient temperature shipping. Follow storage instructions on receipt.
Important This product is for RESEARCH USE ONLY and is not intended for therapeutic or diagnostic use. Not for human or veterinary use.

Calculators

Molarity

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x
More Info

Dilution

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x
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Chemical Data

Purity >95%
Chemical name H-Gly-DL-Cys(1)-DL-Leu-DL-Glu-DL-Phe-DL-Trp-DL-Trp-DL-Lys-DL-Cys(2)-DL-Asn-DL-Pro-DL-Asn-DL-Asp-DL-Asp-DL-Lys-DL-Cys(3)-DL-Cys(1)-DL-Arg-DL-Pro-DL-Lys-DL-Leu-DL-Lys-DL-Cys(2)-DL-Ser-DL-Lys-DL-Leu-DL-Phe-DL-Lys-DL-Leu-DL-Cys(3)-DL-Asn-DL-Phe-DL-Ser-DL-Phe-NH2
Molecular Weight 4095.86
Molecular Formula C185H273N49O45S6
CAS Number 1209500-46-8
PubChem identifier 90488987
SMILES [H]NCC(=O)N[C@H]1CSSC[C@@H]2NC(=O)[C@@H]3CSSC[C@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CC4=CC=CC=C4)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CO)NC(=O)[C@H](CSSC[C@H](NC(=O)[C@H](CCCCN)NC(=O)[C@H](CC4=CNC5=C4C=CC=C5)NC(=O)[C@H](CC4=CNC5=C4C=CC=C5)NC(=O)[C@H](CC4=CC=CC=C4)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CC(C)C)NC1=O)C(=O)N[C@@H](CC(N)=O)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](CCCCN)C(=O)N3)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CCCCN)NC(=O)[C@@H]1CCCN1C(=O)[C@H](CCCNC(N)=N)NC2=O)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CC1=CC=CC=C1)C(=O)N[C@@H](CO)C(=O)N[C@@H](CC1=CC=CC=C1)C(N)=O
InChiKey WVDNTWXIIKNMHY-UHFFFAOYSA-N

References for GsMTx4

References are publications that support the biological activity of the product

  • TACAN Is an Ion Channel Involved in Sensing Mechanical Pain

    Beaulieu-Laroche et al (2020) Cell. 180(5) : 956-967
    Read more (PubMedID: 32084332)

  • The Neuropeptide GsMTx4 Inhibits a Mechanosensitive BK Channel Through the Voltage-Dependent Modification Specific to Mechano-Gating

    Li et al (2019) J Biol Chem. 294(31) : 11892-11909
    Read more (PubMedID: 31201274)

  • GsMTx4: Mechanism of Inhibiting Mechanosensitive Ion Channels

    Gnanasambandam et al (2017) Biophys J. 112(1) : 31-45.
    Read more (PubMedID: 28076814)

  • Human PIEZO1: removing inactivation.

    Bae C et al (2013) Biophys J 105(4) : 880-6.
    Read more (PubMedID: 23972840)

  • A tarantula spider toxin, GsMTx4, reduces mechanical and neuropathic pain.

    Park SP et al (2008) Pain 137(1) : 208-17.
    Read more (PubMedID: 18359568)

Items 1 to 5 of 6 total

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Grouped product items
Order: HB1161
Pack PriceQty
100μg
$282
Piezo and TRP mechanosensitive channels inhibitor
Shipping Info

Standard: $35

Hazardous: $35

Shipped on ice: $35

Shipping will be calculated at checkout

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