Chemogenetics
Chemogenetics research involves the use of small molecule ligands that selectively target genetically-modified receptors (e.g. Designer Receptors Exclusively Activated by Designer Drugs or DREADDs) or chimeric ion channels (Pharmacologically Selective Actuator Modules or PSAMs) to modulate and control neuronal activity. Researchers can save up to 50% on chemogenetics research products from Hello Bio – they are up to half the price of other suppliers and have been reviewed and cited by researchers worldwide.
View products: DREADDs | Peripherally restricted DREADD | PSEMS | CATKLAMP  View Resources: DREADDs Mini-Review | DREADDs for studying GPCRs
CAT335 (HB8146)
Description:K2P2.1 (TREK-1) modulator. Used with ML336 as part of the CATKLAMP chemogenetic strategy. Selectively and irreversibly activates TREK-1CG* but not wild-type K2P2.1 (TREK-1)
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Purity:>98%
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Clozapine (HB1607)
Description:Prototypic, atypical antipsychotic, binds to both serotonin and dopamine receptors
Purity:>99%
- Description:
Water soluble prototypic, atypical antipsychotic. Binds to both serotonin and dopamine receptors.
Purity:>98%
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Clozapine N-oxide (CNO) (freebase) (HB1807)
Description:Prototypical DREADD activator. Clozapine metabolite.
Purity:>98%
- Description:
Dihydrochloride salt of CNO - the prototypical DREADD activator
Purity:>98%
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Deschloroclozapine (DCZ) (HB8555)
Description:Potent, selective and metabolically stable hM3Dq and hM4Di muscarinic DREADD actuator.
Purity:>98%
- Description:
Potent, selective and metabolically stable hM3Dq and hM4Di muscarinic DREADD actuator. Water soluble.
Purity:>99%
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DETQ (HB15406)
Description:Dopamine D1 receptor selective PAM. Enhances genetically encoded dopamine sensor (e.g. dLight) sensitivity.
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Diphenhydramine hydrochloride (DPH) (HB2617)
Description:Histamine H1 antagonist. Potent actuator of a modified hM4Di "GRANPA" DREADD receptor.
Purity:>99%
- Description:
Effective agonist for muscarinic-based DREADDs in vitro and in vivo. Non-CNO chemogenetic actuator. Brain penetrant. Water soluble.
Purity:>98%
